Are we waiting too long for the cardiovascular outcome trials with the glucagon-like peptide-1 receptor agonists?
Doggrell, Sheila (2015) Are we waiting too long for the cardiovascular outcome trials with the glucagon-like peptide-1 receptor agonists? Expert Opinion on Drug Safety, 14(6), pp. 801-805.
Several new medicines are in development for the treatment of type 2 diabetes, and cardiovascular outcome trials are the gold standard for these medicines. This editorial demonstrates that despite being available for over 10 years, there are no cardiovascular outcome studies for any of the glucagon-like peptide-1 (GLP-1) receptor agonists, which demonstrate cardiovascular safety or benefit in subjects with high cardiovascular risk. The author argues that the FDA should be ensuring that clinical outcome studies for subjects with type 2 diabetes and high cardiovascular risk be undertaken in a timelier manner.
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|Item Type:||Journal Article|
|Keywords:||GLP-1 receptor agonists, cardiovascular safety, cardiovascular outcomes, clinical trials, type 2 diabetes|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
|Copyright Owner:||© 2015 Informa UK, Ltd|
|Deposited On:||06 Oct 2015 01:19|
|Last Modified:||24 Apr 2016 16:49|
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