After 10 years of clinical trials with liraglutide, do we know whether it is beneficial in diabetes?

Doggrell, Sheila (2015) After 10 years of clinical trials with liraglutide, do we know whether it is beneficial in diabetes? Review of Recent Clinical Trials, 10(1), pp. 68-77.

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Abstract

Type 2 diabetes remains an escalating world-wide problem, despite a range of treatments. The revelation that insulin secretion is under the control of a gut hormone, glucagon-like peptide 1 (GLP-1), led to a new paradigm in the management of type 2 diabetes. Liraglutide is a long acting GLP-1 receptor agonist used in the treatment of type 2 diabetes. The review considers the clinical trials with liraglutide. There are many comparator trials between liraglutide and other medicines for the treatment of type 2 diabetes, and these trials have shown that liraglutide lowers HbA1c and body weight, and is well tolerated. A large cardiovascular safety trial with liraglutide is presently being undertaken. After 10 years of clinical trials with liraglutide, we do not know whether liraglutide has cardiovascular safety in subjects with type 2 diabetes and high cardiovascular risk. Although this is not a requirement for registration by the Food and Drug Administration (FDA), in my opinion, they should reconsider this. We also do not presently know whether liraglutide has any beneficial effects on clinical cardiovascular outcomes.

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ID Code: 88034
Item Type: Journal Article
Refereed: Yes
Keywords: Clinical outcomes, clinical trials, comparator trials, liraglutide, surrogate endpoints, type 2 diabetes
DOI: 10.2174/1574887110666150417164603
ISSN: 1574-8871
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2015 Bentham Science Publishers
Deposited On: 06 Oct 2015 02:20
Last Modified: 06 Oct 2015 23:18

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