Single-cell-precision microplasma-induced cancer cell apoptosis

Tan, Xiao, Zhao, Shasha, Lei, Qian, Lu, XinPei, He, Guangyuan, & Ostrikov, Kostya (2014) Single-cell-precision microplasma-induced cancer cell apoptosis. PLoS One, 9(6), Article number- e101299.

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Abstract

The issue of single-cell control has recently attracted enormous interest. However, in spite of the presently achievable intracellular-level physiological probing through bio-photonics, nano-probe-based, and some other techniques, the issue of inducing selective, single-cell-precision apoptosis, without affecting neighbouring cells remains essentially open. Here we resolve this issue and report on the effective single-cell-precision cancer cell treatment using the reactive chemistry of the localized corona-type plasma discharge around a needle-like electrode with the spot size ∼1 µm. When the electrode is positioned with the micrometer precision against a selected cell, a focused and highly-localized micro-plasma discharge induces apoptosis in the selected individual HepG2 and HeLa cancer cells only, without affecting any surrounding cells, even in small cell clusters. This is confirmed by the real-time monitoring of the morphological and structural changes at the cellular and cell nucleus levels after the plasma exposure.

Impact and interest:

7 citations in Scopus
9 citations in Web of Science®
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ID Code: 88522
Item Type: Journal Article
Refereed: Yes
DOI: 10.1371/journal.pone.0101299
ISSN: 1932-6203
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: 2014 The Author(s)
Deposited On: 22 Oct 2015 03:23
Last Modified: 16 Nov 2016 04:34

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