Prognostic value of BRAF mutations in localized cutaneous melanoma

Nagore, Eduardo, Requena, Celia, Traves, Victor, Guillen, Carlos, Hayward, Nicholas K, Whiteman, David C, & Hacker, Elke (2014) Prognostic value of BRAF mutations in localized cutaneous melanoma. Journal of the American Academy of Dermatology, 70(5), pp. 858-862.

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Abstract

BACKGROUND: BRAF mutations are frequent in melanoma but their prognostic significance remains unclear. OBJECTIVE: We sought to further evaluate the prognostic value of BRAF mutations in localized cutaneous melanoma. METHODS: We undertook an observational retrospective study of 147 patients with localized invasive (stages I and II) cutaneous melanomas to determine the prognostic value of BRAF mutation status. RESULTS: After a median follow-up of 48 months, patients with localized melanomas with BRAF-mutant melanomas exhibited poorer disease-free survival than those with BRAF-wt genotype (hazard ratio 2.2, 95% confidence interval 1.1-4.3) even after adjustment for Breslow thickness, tumor ulceration, location, age, sex, and tumor mitotic rate. LIMITATIONS: The retrospective design and the small number of events are limitations. CONCLUSIONS: Our findings suggest that reappraisal of clinical treatment approaches for patients with localized melanoma harboring tumors with BRAF mutation might be warranted

Impact and interest:

15 citations in Scopus
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12 citations in Web of Science®

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ID Code: 88527
Item Type: Journal Article
Refereed: Yes
Keywords: BRAF, localized, melanoma, NRAS, prognosis, survival
DOI: 10.1016/j.jaad.2013.10.064
ISSN: 0190-9622
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Deposited On: 02 Nov 2015 02:02
Last Modified: 02 Nov 2015 02:02

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