Adjustable stiffness, external fixator for the rat femur osteotomy and segmental bone defect models

Glatt, Vaida & Matthys, Romano (2014) Adjustable stiffness, external fixator for the rat femur osteotomy and segmental bone defect models. Journal of Visualized Experiments, 2014(92), pp. 1-14.

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Abstract

The mechanical environment around the healing of broken bone is very important as it determines the way the fracture will heal. Over the past decade there has been great clinical interest in improving bone healing by altering the mechanical environment through the fixation stability around the lesion. One constraint of preclinical animal research in this area is the lack of experimental control over the local mechanical environment within a large segmental defect as well as osteotomies as they heal. In this paper we report on the design and use of an external fixator to study the healing of large segmental bone defects or osteotomies. This device not only allows for controlled axial stiffness on the bone lesion as it heals, but it also enables the change of stiffness during the healing process in vivo. The conducted experiments have shown that the fixators were able to maintain a 5 mm femoral defect gap in rats in vivo during unrestricted cage activity for at least 8 weeks. Likewise, we observed no distortion or infections, including pin infections during the entire healing period. These results demonstrate that our newly developed external fixator was able to achieve reproducible and standardized stabilization, and the alteration of the mechanical environment of in vivo rat large bone defects and various size osteotomies. This confirms that the external fixation device is well suited for preclinical research investigations using a rat model in the field of bone regeneration and repair.

Impact and interest:

1 citations in Scopus
1 citations in Web of Science®
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ID Code: 88546
Item Type: Journal Article
Refereed: Yes
Keywords: Medicine, Issue 92, external fixator, bone healing, small animal model, large bone defect and osteotomy model, rat model, mechanical environment,, mechanobiology
DOI: 10.3791/51558
ISSN: 1940-087X
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 01 Nov 2015 23:25
Last Modified: 25 Jun 2017 20:01

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