Fractional diffusion models of cardiac electrical propagation: Role of structural heterogeneity in dispersion of repolarization

Bueno-Orovio, Alfonso, Kay, David, Grau, Vicente, Rodriguez, Blanca, & Burrage, Kevin (2014) Fractional diffusion models of cardiac electrical propagation: Role of structural heterogeneity in dispersion of repolarization. Journal of the Royal Society Interface, 11(97), pp. 1-12.

View at publisher (open access)

Abstract

Impulse propagation in biological tissues is known to be modulated by structural heterogeneity. In cardiac muscle, improved understanding on how this heterogeneity influences electrical spread is key to advancing our interpretation of dispersion of repolarization. We propose fractional diffusion models as a novel mathematical description of structurally heterogeneous excitable media, as a means of representing the modulation of the total electric field by the secondary electrical sources associated with tissue inhomogeneities. Our results, analysed against in vivo human recordings and experimental data of different animal species, indicate that structural heterogeneity underlies relevant characteristics of cardiac electrical propagation at tissue level. These include conduction effects on action potential (AP) morphology, the shortening of AP duration along the activation pathway and the progressive modulation by premature beats of spatial patterns of dispersion of repolarization. The proposed approach may also have important implications in other research fields involving excitable complex media.

Impact and interest:

33 citations in Scopus
Search Google Scholar™
26 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 88594
Item Type: Journal Article
Refereed: Yes
DOI: 10.1098/rsif.2014.0352
ISSN: 1742-5689
Divisions: Current > Schools > School of Mathematical Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 The Authors
Deposited On: 06 Nov 2015 00:28
Last Modified: 06 Nov 2015 00:28

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page