Mimicking breast cancer-induced bone metastasis in vivo: Current transplantation models and advanced humanized strategies

Thibaudeau, Laure, Quent, Verena, Holzapfel, Boris, Taubenberger, Anna, Straub, Melanie, & Hutmacher, Dietmar (2014) Mimicking breast cancer-induced bone metastasis in vivo: Current transplantation models and advanced humanized strategies. Cancer and Metastasis Reviews, 33(2), pp. 721-735.

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Bone metastasis is a complication that occurs in 80 % of women with advanced breast cancer. Despite the prevalence of bone metastatic disease, the avenues for its clinical management are still restricted to palliative treatment options. In fact, the underlying mechanisms of breast cancer osteotropism have not yet been fully elucidated due to a lack of suitable in vivo models that are able to recapitulate the human disease. In this work, we review the current transplantation-based models to investigate breast cancer-induced bone metastasis and delineate the strengths and limitations of the use of different grafting techniques, tissue sources, and hosts. We further show that humanized xenograft models incorporating human cells or tissue grafts at the primary tumor site or the metastatic site mimic more closely the human disease. Tissue-engineered constructs are emerging as a reproducible alternative to recapitulate functional humanized tissues in these murine models. The development of advanced humanized animal models may provide better platforms to investigate the mutual interactions between human cancer cells and their microenvironment and ultimately improve the translation of preclinical drug trials to the clinic.

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12 citations in Scopus
10 citations in Web of Science®
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ID Code: 88599
Item Type: Journal Article
Refereed: Yes
Keywords: Bone metastasis Breast cancer Osteotropism Humanized xenograft model Tissue engineering
DOI: 10.1007/s10555-014-9499-z
ISSN: 0167-7659
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 Springer Science+Business Media New York
Deposited On: 05 Nov 2015 22:36
Last Modified: 02 Sep 2016 03:27

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