Mimicking breast cancer-induced bone metastasis in vivo: Current transplantation models and advanced humanized strategies
Thibaudeau, Laure, Quent, Verena, Holzapfel, Boris, Taubenberger, Anna, Straub, Melanie, & Hutmacher, Dietmar (2014) Mimicking breast cancer-induced bone metastasis in vivo: Current transplantation models and advanced humanized strategies. Cancer and Metastasis Reviews, 33(2), pp. 721-735.
Bone metastasis is a complication that occurs in 80 % of women with advanced breast cancer. Despite the prevalence of bone metastatic disease, the avenues for its clinical management are still restricted to palliative treatment options. In fact, the underlying mechanisms of breast cancer osteotropism have not yet been fully elucidated due to a lack of suitable in vivo models that are able to recapitulate the human disease. In this work, we review the current transplantation-based models to investigate breast cancer-induced bone metastasis and delineate the strengths and limitations of the use of different grafting techniques, tissue sources, and hosts. We further show that humanized xenograft models incorporating human cells or tissue grafts at the primary tumor site or the metastatic site mimic more closely the human disease. Tissue-engineered constructs are emerging as a reproducible alternative to recapitulate functional humanized tissues in these murine models. The development of advanced humanized animal models may provide better platforms to investigate the mutual interactions between human cancer cells and their microenvironment and ultimately improve the translation of preclinical drug trials to the clinic.
Impact and interest:
Citation counts are sourced monthly from and citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||Bone metastasis Breast cancer Osteotropism Humanized xenograft model Tissue engineering|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2014 Springer Science+Business Media New York|
|Deposited On:||05 Nov 2015 22:36|
|Last Modified:||02 Sep 2016 03:27|
Repository Staff Only: item control page