Melt electrospinning of poly(epsilon-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing

Brown, Toby, Edin, Fredrik, Detta, Nicola, Skelton, Anthony, Hutmacher, Dietmar, & Dalton, Paul (2014) Melt electrospinning of poly(epsilon-caprolactone) scaffolds: Phenomenological observations associated with collection and direct writing. Materials Science and Engineering C: Materials for Biological Applications, 45(1 Dec), pp. 698-708.

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Abstract

Melt electrospinning and its additive manufacturing analogue, melt electrospinning writing (MEW), are two processes which can produce porous materials for applications where solvent toxicity and accumulation in solution electrospinning are problematic. This study explores the melt electrospinning of poly(ε-caprolactone) (PCL) scaffolds, specifically for applications in tissue engineering. The research described here aims to inform researchers interested in melt electrospinning about technical aspects of the process. This includes rapid fiber characterization using glass microscope slides, allowing influential processing parameters on fiber morphology to be assessed, as well as observed fiber collection phenomena on different collector substrates. The distribution and alignment of melt electrospun PCL fibers can be controlled to a certain degree using patterned collectors to create large numbers of scaffolds with shaped macroporous architectures. However, the buildup of residual charge in the collected fibers limits the achievable thickness of the porous template through such scaffolds. One challenge identified for MEW is the ability to control charge buildup so that fibers can be placed accurately in close proximity, and in many centimeter heights. The scale and size of scaffolds produced using MEW, however, indicate that this emerging process will fill a technological niche in biofabrication.

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8 citations in Scopus
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18 citations in Web of Science®

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ID Code: 88626
Item Type: Journal Article
Refereed: Yes
Keywords: Electrospinning; Fibers; Tissue engineering; 3D printing; Additive manufacturing; Electrohydrodynamic writing
DOI: 10.1016/j.msec.2014.07.034
ISSN: 0928-4931
Copyright Owner: Copyright 2014 Elsevier B.V.
Deposited On: 04 Nov 2015 23:05
Last Modified: 04 Nov 2015 23:05

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