Development and characterisation of a new bioink for additive tissue manufacturing

Melchels, Ferry P.W., Dhert, Wouter J.A., Hutmacher, Dietmar W., & Malda, Jos (2014) Development and characterisation of a new bioink for additive tissue manufacturing. Journal of Materials Chemistry B, 2(16), pp. 2282-2289.

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Additive manufacturing forms a potential route towards economically viable production of cellular constructs for tissue engineering. Hydrogels are a suitable class of materials for cell delivery and 3D culture, but are generally unsuitable as construction materials. Gelatine-methacrylamide is an example of such a hydrogel system widely used in the field of tissue engineering, e.g. for cartilage and cardiovascular applications. Here we show that by the addition of gellan gum to gelatine-methacrylamide and tailoring salt concentrations, rheological properties such as pseudo-plasticity and yield stress can be optimised towards gel dispensing for additive manufacturing processes. In the hydrogel formulation, salt is partly substituted by mannose to obtain isotonicity and prevent a reduction in cell viability. With this, the potential of this new bioink for additive tissue manufacturing purposes is demonstrated.

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26 citations in Web of Science®

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ID Code: 88671
Item Type: Journal Article
Refereed: Yes
DOI: 10.1039/C3TB21280G
ISSN: 2050-7518
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 01 Nov 2015 23:06
Last Modified: 01 Nov 2015 23:18

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