Targeting EMT in cancer: opportunities for pharmacological intervention

Davis, Felicity, Stewart, Teneale, Thompson, Erik W, & Monteith, Gregory (2014) Targeting EMT in cancer: opportunities for pharmacological intervention. Trends in Pharmacological Sciences, 35(9), pp. 479-488.

View at publisher


•EMT is important for embryonic development, wound healing, and placentation. •Some cancers appear to exploit this process for increased metastatic potential. •Therefore, this pathway is of great therapeutic interest in the treatment of cancer.

The spread of cancer cells to distant organs represents a major clinical challenge in the treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key regulator of metastasis in some cancers by conferring an invasive phenotype. As well as facilitating metastasis, EMT is thought to generate cancer stem cells and contribute to therapy resistance. Therefore, the EMT pathway is of great therapeutic interest in the treatment of cancer and could be targeted either to prevent tumor dissemination in patients at high risk of developing metastatic lesions or to eradicate existing metastatic cancer cells in patients with more advanced disease. In this review, we discuss approaches for the design of EMT-based therapies in cancer, summarize evidence for some of the proposed EMT targets, and review the potential advantages and pitfalls of each approach

Impact and interest:

35 citations in Scopus
Search Google Scholar™
31 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 88684
Item Type: Journal Article
Refereed: Yes
Keywords: Epithelial-mesenchymal transition (EMT), cancer, metastasis, invasion, therapy resistance, cancer stem cells, mesenchymal-epithelial transition (MET)
DOI: 10.1016/
ISSN: 0165-6147
Copyright Owner: © 2014 Elsevier Ltd
Deposited On: 02 Nov 2015 01:33
Last Modified: 02 Nov 2015 01:33

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page