TMIO-pyrimid hybrids are profluorescent, site-directed spin labels for nucleic acids
Chalmers, Benjamin, Saha, Subham, Nguyen, Tri, McMurtrie, John, Sigurdsson, Snorri, Bottle, Steven, & Masters, Kye (2014) TMIO-pyrimid hybrids are profluorescent, site-directed spin labels for nucleic acids. Organic Letters, 16(21), pp. 5528-5531.
We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, which can be detected by electron paramagnetic resonance (EPR) techniques. They also have promising properties for fluorimetric analysis, as their fluorescent spin-quenched derivatives exhibit a significant Stokes shift
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||© 2014 American Chemical Society|
|Deposited On:||02 Nov 2015 00:38|
|Last Modified:||02 Nov 2015 00:38|
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