TMIO-pyrimid hybrids are profluorescent, site-directed spin labels for nucleic acids

Chalmers, Benjamin, Saha, Subham, Nguyen, Tri, McMurtrie, John, Sigurdsson, Snorri, Bottle, Steven, & Masters, Kye (2014) TMIO-pyrimid hybrids are profluorescent, site-directed spin labels for nucleic acids. Organic Letters, 16(21), pp. 5528-5531.

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Abstract

We report the synthesis of a new class of molecules which are hybrids of long-lived tetramethylisoindolinoxyl (TMIO) radicals and the pyrido[1,2-a]benzimidazole (PyrImid) scaffold. These compounds represent a new lead for noncovalently binding nucleic acid probes, as they interact with nucleic acids with previously unreported C (DNA) and C/U (RNA) complementarity, which can be detected by electron paramagnetic resonance (EPR) techniques. They also have promising properties for fluorimetric analysis, as their fluorescent spin-quenched derivatives exhibit a significant Stokes shift

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10 citations in Scopus
11 citations in Web of Science®
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ID Code: 88688
Item Type: Journal Article
Refereed: Yes
DOI: 10.1021/ol502003a
ISSN: 1523-7060
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: © 2014 American Chemical Society
Deposited On: 02 Nov 2015 00:38
Last Modified: 25 Jun 2017 21:01

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