Magnetic and morphological properties of ferrofluid-impregnated hydroxyapatite/collagen scaffolds
Riminucci, Alberto, Dionigi, Chiara, Pernechele, Chiara, De Pasquale, Giulia, De Caro, Tilde, Ingo, Gabriel Maria, Mezzadri, Francesco, Bock, Nathalie, Solzi, Massimo, Padeletti, Giuseppina, Sandri, Monica, Tampieri, Anna, & Dediu, V. Alek (2014) Magnetic and morphological properties of ferrofluid-impregnated hydroxyapatite/collagen scaffolds. Science of Advanced Materials, 6(12), pp. 2679-2687.
In this article we present the morphological and magnetic characterization of ferrofluid-impregnated biomimetic scaffolds made of hydroxyapatite and collagen used for bone reconstruction. We describe an innovative and simple impregnation process by which the ferrofluid is firmly adsorbed onto the hydroxyapatite/collagen scaffolds. The process confers sufficient magnetization to attract potential magnetic carriers, which may be used to transport bioactive agents that favour bone regeneration. The crystalline structure of the magnetite contained in the ferrofluid is preserved and its quantity, estimated from the weight gain due to the impregnation process, is consistent with that obtained from energy dispersive X-ray spectroscopy. The magnetization, measured with a superconducting quantum interference device, is uniform throughout the scaffolds, demonstrating the efficiency of the impregnation process. The field emission gun scanning electron microscopy characterization demonstrates that the process does not alter the morphology of the hydroxyapatite/collagen scaffolds, which is essential for the preservation of their bioactivity and consequently for their effectiveness in promoting bone formation.
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|Item Type:||Journal Article|
|Keywords:||BONE REGENERATION; COLLAGEN; HYDROXYAPATITE; MAGNETIC NANOPARTICLES; MAGNETIC SCAFFOLDS|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2014 American Scientific Publishers|
|Deposited On:||30 Oct 2015 00:35|
|Last Modified:||30 Oct 2015 00:35|
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