Antimicrobial treatment of non-cystic fibrosis bronchiectasis

Grimwood, Keith, Bell, Scott, & Chang, Anne (2014) Antimicrobial treatment of non-cystic fibrosis bronchiectasis. Expert Review of Anti-Infective Therapy, 12(10), pp. 1277-1296.

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Bronchiectasis unrelated to cystic fibrosis is characterized by chronic wet or productive cough, recurrent exacerbations and irreversible bronchial dilatation. After antibiotics and vaccines became available and living standards in affluent countries improved, its resulting reduced prevalence meant bronchiectasis was considered an ‘orphan disease’. This perception has changed recently with increasing use of CT scans to diagnose bronchiectasis, including in those with severe chronic obstructive pulmonary disease or ‘difficult to control’ asthma, and adds to its already known importance in non-affluent countries and disadvantaged Indigenous communities. Following years of neglect, there is renewed interest in identifying the pathogenetic mechanisms of bronchiectasis, including the role of infection, and conducting clinical trials. This is providing much needed evidence to guide antimicrobial therapy, which has relied previously upon extrapolating treatments used in cystic fibrosis and chronic obstructive pulmonary disease. While many knowledge gaps and management challenges remain, the future is improving for patients with bronchiectasis.

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6 citations in Scopus
7 citations in Web of Science®
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ID Code: 88741
Item Type: Journal Article
Refereed: Yes
Keywords: amikaci, azithromycin, bronchiectasis, colistin, Haemophilus influenzae, microbiota, non-tuberculous mycobacteria, Pseudomonas aeruginosa, Respiratory viruses, tobramycin
DOI: 10.1586/14787210.2014.952282
ISSN: 1478-7210
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2014 Informa UK Ltd
Deposited On: 30 Oct 2015 03:25
Last Modified: 30 Oct 2015 03:25

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