In vitro pre-vascularisation of tissue-engineered constructs: A co-culture perspective

Baldwin, Jeremy, Antille, Melanie, Bonda, Ulrich, de Juan Pardo, Elena M., Khosrotehrani, Kiarash, Ivanovski, Saso, Petcu, Eugen Bogdan, & Hutmacher, Dietmar Werner (2014) In vitro pre-vascularisation of tissue-engineered constructs: A co-culture perspective. Vascular Cell, 6(13).

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Abstract

In vitro pre-vascularization is one of the main vascularization strategies in the tissue engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to implantation provides researchers with a greater degree of control over the fate of the cells. However, balancing the diverse range of different cell culture parameters in vitro is seldom easy and in most cases, especially in highly vascularized tissues, more than one cell type will reside within the cell culture system. Culturing multiple cell types in the same construct presents its own unique challenges and pitfalls. The following review examines endothelial-driven vascularization and evaluates the direct and indirect role other cell types have in vessel and capillary formation. The article then analyses the different parameters researchers can modulate in a co-culture system in order to design optimal tissue-engineered constructs to match desired clinical applications.

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11 citations in Scopus
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ID Code: 88867
Item Type: Journal Article
Refereed: Yes
Keywords: Co-culture; Vascularisation; Tissue engineering; Matrices
DOI: 10.1186/2045-824X-6-13
ISSN: 2045-824X
Copyright Owner: Copyright 2014 Baldwin et al.; licensee BioMed Central Ltd.
Copyright Statement: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Deposited On: 08 Oct 2015 06:02
Last Modified: 08 Oct 2015 06:02

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