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Effects of low dose lithium on hippocampal neuropathology in people at ultra-high risk for psychosis

Wood, Stephen J. , Berger, Gregor , Dell'Ollio, Margaret, Hamer, Clare A., Wellard, R. Mark, Pell, Gaby S., Phillips, L. J., Nelson, Barnaby, Manji, Husseini, Jackson, Graeme J. , Pantelis, Christos , & McGorry, Patrick D. (2007) Effects of low dose lithium on hippocampal neuropathology in people at ultra-high risk for psychosis. In Biological Psychiatry, Society of Biological Psychiatry, San Diego, USA, 259S-260S.

Abstract

Background: Indicated intervention prior to the onset of psychosis may help to delay, attenuate or even prevent the illness. To date, successful intervention trials using atypical antipsychotics and/or cognitive behavioural therapy have been reported, but it is not clear that these treatments are targeting the underlying brain pathology. Given our previous findings of progressive grey matter loss over the transition to psychosis, agents that can prevent this, such as lithium, might be useful for preventing or delaying the onset of psychosis. Methods: In this open-label trial, 11 ultra-high-risk patients who received low- dose lithium treatment for four months were compared with 10 similar patients who received only needs-based intervention. Magnetic resonance imaging, including T2 relaxometry and proton spectroscopy was performed prior to initiation of treatment and after four months. Results: Hippocampal T2 declined significantly in the treatment group (p=0.018). No significant group x time effects were seen for brain metabolites, although N-acetyl aspartate (NAA), myo-inositol, creatine and choline all tended to increase with lithium administration and decrease or remain unchanged in the comparison group. Conclusions: Decreased T2 relaxation time and increased concentrations of NAA are indicators of increased neuronal function/viability. Low-dose lithium may help regulate synaptic pruning and reduce neuronal dysfunction associated with the onset of psychosis.

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ID Code: 8892
Item Type: Conference Paper
Additional Information: For more information, please refer to the conference's website (see hypertext link) or contact the author. Author contact details: m.wellard@qut.edu.au
Additional URLs:
Keywords: litium, psychosis, MRS, MR spectroscopy, hippocamus, neuropathy
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > COGNITIVE SCIENCE (170200) > Neurocognitive Patterns and Neural Networks (170205)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100) > Medical Biochemistry and Metabolomics not elsewhere classified (110199)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Sensory Processes Perception and Performance (170112)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600) > Systems Physiology (111603)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Neurochemistry (060105)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Metabolism (060104)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Medical Biotechnology not elsewhere classified (100499)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600) > Cell Physiology (111601)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > PHYSIOLOGY (060600) > Animal Physiology - Cell (060602)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL BIOCHEMISTRY AND METABOLOMICS (110100)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL PHYSIOLOGY (111600)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Central Nervous System (110903)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Cellular Nervous System (110902)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NEUROSCIENCES (110900) > Neurology and Neuromuscular Diseases (110904)
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Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 The Authors
Deposited On: 07 Aug 2007
Last Modified: 11 Aug 2011 04:24

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