Dissecting the prostate cancer stem cell niche inside the bone marrow

Tang, Kai Dun (2015) Dissecting the prostate cancer stem cell niche inside the bone marrow. PhD by Publication, Queensland University of Technology.


Prostate cancer frequently metastasizes to bone, which becomes incurable; yet how cancer cells manage to migrate and grow inside the bone remains unknown. In this study I have discovered that both bone and fat cells within the bone marrow actively promote the survival and expansion of prostate cancer cells, and have subsequently developed approaches that can effectively inhibit these processes. Therefore, my work offers opportunities for the development of new prognostic and therapeutic approaches against metastatic prostate cancer and have the potential for improving the treatment outcome of the patients.

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24 since deposited on 06 Apr 2016
24 in the past twelve months

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ID Code: 88935
Item Type: QUT Thesis (PhD by Publication)
Supervisor: Ling, Patrick & Clements, Judith
Keywords: Prostate Cancer, Cancer Stem Cells, Bone Marrow, Adipocytes, Bone Metastasis, Drug Resistance, Angiopoietin-1/Tie-2, Cholescystokinin, Cathepsin B
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 06 Apr 2016 05:38
Last Modified: 06 Apr 2016 05:38

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