MicroRNA regulation of epithelial-to-mesenchymal transition during re-epithelialisation: Assessing an open wound

Wager, Lucas James & Leavesley, David I. (2015) MicroRNA regulation of epithelial-to-mesenchymal transition during re-epithelialisation: Assessing an open wound. Wound Practice and Research, 23(3), pp. 132-142.

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It is becoming increasing clear that microRNAs contribute to the regulation of many biological processes, including wound healing. After injury, keratinocytes need to undergo what is known as an epithelial-to-mesenchymal transition (EMT) to initiate re-epithelialisation. During this process, keratinocytes reduce their attachment to the underlying matrix, extend membrane protrusions, become motile and migrate over the wound bed, affecting wound closure. MicroRNAs that regulate EMT are aberrantly upregulated in keratinocytes at the edge of non-healing wounds and potentially play a role in the chronicity of these wounds. In vitro and in vivo, downregulation of these microRNAs promotes EMT and migration, facilitating re-epithelialisation in wound models. This review will focus on the role of microRNAs that regulate or have potential to regulate EMT and re-epithelialisation during wound healing

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ID Code: 88942
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: microRNA, epithelial-to-mesenchymal transition, healing, wound, re-epithelialisation, skin
ISSN: 1837-6304
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OTHER MEDICAL AND HEALTH SCIENCES (119900) > Medical and Health Sciences not elsewhere classified (119999)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Australian Wound Management Association
Deposited On: 11 Oct 2015 23:37
Last Modified: 13 Oct 2015 22:33

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