Imaging tumour distribution of a polymeric drug delivery platformin vivoby PET-MRI
Puttick, Simon, Boase, Nathan R. B., Blakey, Idriss, & Thurecht, Kristofer J. (2014) Imaging tumour distribution of a polymeric drug delivery platformin vivoby PET-MRI. Journal of Chemcial Technology and Biotechnology, 90(7), pp. 1237-1244.
Background Over the past decade, molecular imaging has played a key role in the progression of drug delivery platforms from concept to commercialisation. Of the molecular imaging techniques commonly utilised, positron emission tomography (PET) can yield a breadth of information not easily accessible by other methodologies and when combined with other complementary imaging modalities, is a powerful tool for pre- and clinical development of therapeutics. However, very little research has focussed on the information available from complimentary imaging modalities. This paper reports on the data-rich methodologies of contrast enhanced PET/CT and PET/MRI for probing efficacy of polymer drug delivery platforms.
Results The information available from an ExiTron nano 6000 contrast enhanced PET/CT and a gadolinium (Gd) enhanced PET/MRI image of a 64Cu labeled HBP in the same mouse was qualitatively compared.
Conclusions Gd contrast enhanced PET/MRI offers a powerful methodology for investigating the distribution of polymer drug delivery platforms in vivo and throughout a tumour volume. Furthermore, information about depth of penetration away from primary blood vessels can be gleaned, potentially leading to development of more efficacious delivery vehicles for clinical use.
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|Item Type:||Journal Article|
|Keywords:||Positron emission tomography, Magnetic resonance imaging, Drug delivery, Molecular imaging|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2014 John Wiley & Sons Ltd.|
|Deposited On:||15 Mar 2016 05:51|
|Last Modified:||18 Mar 2016 01:49|
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