Imaging tumour distribution of a polymeric drug delivery platformin vivoby PET-MRI

Puttick, Simon, Boase, Nathan R. B., Blakey, Idriss, & Thurecht, Kristofer J. (2014) Imaging tumour distribution of a polymeric drug delivery platformin vivoby PET-MRI. Journal of Chemcial Technology and Biotechnology, 90(7), pp. 1237-1244.

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Abstract

Background Over the past decade, molecular imaging has played a key role in the progression of drug delivery platforms from concept to commercialisation. Of the molecular imaging techniques commonly utilised, positron emission tomography (PET) can yield a breadth of information not easily accessible by other methodologies and when combined with other complementary imaging modalities, is a powerful tool for pre- and clinical development of therapeutics. However, very little research has focussed on the information available from complimentary imaging modalities. This paper reports on the data-rich methodologies of contrast enhanced PET/CT and PET/MRI for probing efficacy of polymer drug delivery platforms.

Results The information available from an ExiTron nano 6000 contrast enhanced PET/CT and a gadolinium (Gd) enhanced PET/MRI image of a 64Cu labeled HBP in the same mouse was qualitatively compared.

Conclusions Gd contrast enhanced PET/MRI offers a powerful methodology for investigating the distribution of polymer drug delivery platforms in vivo and throughout a tumour volume. Furthermore, information about depth of penetration away from primary blood vessels can be gleaned, potentially leading to development of more efficacious delivery vehicles for clinical use.

Impact and interest:

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ID Code: 89090
Item Type: Journal Article
Refereed: Yes
Keywords: Positron emission tomography, Magnetic resonance imaging, Drug delivery, Molecular imaging
DOI: 10.1002/jctb.4489
ISSN: 0268-2575
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 John Wiley & Sons Ltd.
Deposited On: 15 Mar 2016 05:51
Last Modified: 18 Mar 2016 01:49

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