Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imagingin vivo

Rolfe, Barbara E., Blakey, Idriss, Squires, Oliver, Peng, Hui, Boase, Nathan R.B., Alexander, Cameron, Parsons, Peter G., Boyle, Glen M., Whittaker, Andrew K., & Thurecht, Kristofer J. (2014) Multimodal polymer nanoparticles with combined 19F magnetic resonance and optical detection for tunable, targeted, multimodal imagingin vivo. Journal of the American Chemical Society, 136(6), pp. 2413-2419.

View at publisher


Understanding the complex nature of diseased tissue in vivo requires development of more advanced nanomedicines, where synthesis of multifunctional polymers combines imaging multimodality with a biocompatible, tunable, and functional nanomaterial carrier. Here we describe the development of polymeric nanoparticles for multimodal imaging of disease states in vivo. The nanoparticle design utilizes the abundant functionality and tunable physicochemical properties of synthetically robust polymeric systems to facilitate targeted imaging of tumors in mice. For the first time, high-resolution 19F/1H magnetic resonance imaging is combined with sensitive and versatile fluorescence imaging in a polymeric material for in vivo detection of tumors. We highlight how control over the chemistry during synthesis allows manipulation of nanoparticle size and function and can lead to very high targeting efficiency to B16 melanoma cells, both in vitro and in vivo. Importantly, the combination of imaging modalities within a polymeric nanoparticle provides information on the tumor mass across various size scales in vivo, from millimeters down to tens of micrometers.

Impact and interest:

44 citations in Scopus
Search Google Scholar™
41 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 89092
Item Type: Journal Article
Refereed: Yes
Keywords: Chemistry, Business and Management, Specialist Studies in Education, Marketing
DOI: 10.1021/ja410351h
ISSN: 1520-5126
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2014 American Chemical Society
Deposited On: 16 Mar 2016 04:27
Last Modified: 18 Mar 2016 01:35

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page