Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo

Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R.B., Veedu, Rakesh N., & Thurecht, Kristofer J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49(37), pp. 3836-3838.

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Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer)while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.

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13 citations in Scopus
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14 citations in Web of Science®

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ID Code: 89093
Item Type: Journal Article
Refereed: Yes
DOI: 10.1039/c3cc00127j
ISSN: 1364-548X
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Royal Society of Chemistry
Deposited On: 15 Mar 2016 23:10
Last Modified: 18 Mar 2016 02:01

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