Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R.B., Veedu, Rakesh N., & Thurecht, Kristofer J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49(37), pp. 3836-3838.
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer)while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
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|Item Type:||Journal Article|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2013 Royal Society of Chemistry|
|Deposited On:||15 Mar 2016 23:10|
|Last Modified:||18 Mar 2016 02:01|
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