Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes

Greer, R. M., Portelli, S. L., Hung, B. S. M., Cleghorn, Geoffrey J., McMahon, S. K., Batch, J. A., & Conwell, L. S. (2013) Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes. Pediatric Diabetes, 14(1), pp. 31-41.

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Vitamin D is synthesised in the skin through the action of UVB radiation (sunlight), and 25-hydroxy vitamin D (25OHD) measured in serum as a marker of vitamin D status. Several studies, mostly conducted in high latitudes, have shown an association between type 1 diabetes mellitus (T1DM) and low serum 25OHD. We conducted a case-control study to determine whether, in a sub-tropical environment with abundant sunlight (latitude 27.5°S), children with T1DM have lower serum vitamin D than children without diabetes. Fifty-six children with T1DM (14 newly diagnosed) and 46 unrelated control children participated in the study. Serum 25OHD, 1,25-dihydroxy vitamin D (1,25(OH)2D) and selected biochemical indices were measured. Vitamin D receptor (VDR) polymorphisms Taq1, Fok1, and Apa1 were genotyped. Fitzpatrick skin classification, self-reported daily hours of outdoor exposure, and mean UV index over the 35d prior to blood collection were recorded. Serum 25OHD was lower in children with T1DM (n=56) than in controls (n=46) [mean (95%CI)=78.7 (71.8-85.6) nmol/L vs. 91.4 (83.5-98.7) nmol/L, p=0.02]. T1DM children had lower self-reported outdoor exposure and mean UV exposure, but no significant difference in distribution of VDR polymorphisms. 25OHD remained lower in children with T1DM after covariate adjustment. Children newly diagnosed with T1DM had lower 1,25(OH)2D [median (IQR)=89 (68-122) pmol/L] than controls [121 (108-159) pmol/L, p=0.03], or children with established diabetes [137 (113-153) pmol/L, p=0.01]. Children with T1DM have lower 25OHD than controls, even in an environment of abundant sunlight. Whether low vitamin D is a risk factor or consequence of T1DM is unknown. © 2012 John Wiley & Sons A/S.

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ID Code: 89182
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :11
Export Date: 1 September 2015
Correspondence Address: Greer, R.M.; Queensland Childreńs Medical Research Institute, Royal Childreńs Hospital, University of Queensland, Herston, Qld 4029, Australia; email:
Keywords: Paediatrics, Type 1 diabetes, Vitamin D, Vitamin D receptor, calcifediol, calcitriol, article, Australia, blood sampling, case control study, child, controlled study, disease association, disease classification, disease marker, female, fitzpatrick skin classification, genotype, human, insulin dependent diabetes mellitus, latitude, major clinical study, male, priority journal, risk factor, school child, self report, single nucleotide polymorphism, sunlight, tropic climate, ultraviolet B radiation, vitamin blood level, vitamin supplementation, Adolescent, Case-Control Studies, Child, Preschool, Diabetes Mellitus, Type 1, Humans, Parathyroid Hormone, Polymorphism, Restriction Fragment Length, Receptors, Calcitriol, Vitamin D Deficiency
DOI: 10.1111/j.1399-5448.2012.00890.x
ISSN: 1399-543X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 20 Oct 2015 01:36
Last Modified: 27 Oct 2015 03:01

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