Quality of life in children with Crohn disease

Hill, R. J., Lewindon, P. J., Muir, R., Grangé, I., Connor, F. L., Ee, L., Withers, G. D., Cleghorn, Geoffrey J., & Davies, P. S. W. (2010) Quality of life in children with Crohn disease. Journal of Pediatric Gastroenterology and Nutrition, 51(1), pp. 35-40.

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Objectives: Quality of life (QOL) is reportedly poor in children with Crohn disease (CD) but improves with increasing disease duration. This article aims to detail QOL in a cohort of Australian children with CD in relation to disease duration, disease activity, and treatment. MATERIALS AND METHODS: QOL, assessed using the IMPACT-III questionnaire, and disease activity measures, assessed using the Pediatric Crohn's Disease Activity Index (PCDAI), were available in 41 children with CD. For this cohort, a total of 186 measurements of both parameters were available. Results: QOL was found to be significantly lower, and disease activity significantly higher (F = 31.1, P = 0.00), in patients within 6 months of their diagnosis compared with those up to 2.5 years, up to 5 years, and beyond 5 years since diagnosis. Higher disease activity was associated with poorer QOL (r =-0.51, P = 0.00). Total QOL was highest in children on nil medications and lowest in children on enteral nutrition. The PCDAI (t =-6.0, P = 0.00) was a significant predictor of QOL, with the clinical history (t =-6.9, P = 0.00) and examination (t =-2.9, P = 0.01) sections of the PCDAI significantly predicting QOL. Disease duration, age, or sex was neither related to nor significant predictors of QOL, but height z score and type of treatment approached significance. Conclusions: Children with CD within 6 months of their diagnosis have impaired QOL compared with those diagnosed beyond 6 months. These patients, along with those with growth impairment, ongoing elevated disease activity with abdominal pain, diarrhoea and/or perirectal and extraintestinal complications, may benefit from regular assessments of QOL as part of their clinical treatment. © 2010 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

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ID Code: 89188
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :10
Export Date: 1 September 2015
Correspondence Address: Hill, R. J.; Children's Nutrition Research Centre, Discipline of Paediatrics and Child Health, University of Queensland, Royal Children's Hospital, Level 3, Herston, QLD 4029, Australia; email: rj.hill@uq.edu.au
Keywords: children, Crohn disease, disease activity, disease duration, quality of life, type of treatment, abdominal pain, adolescent, article, Australia, body height, child, clinical article, cohort analysis, controlled study, enteric feeding, female, growth inhibition, human, male, pediatrics, prediction, predictor variable, priority journal, questionnaire, school child, Cohort Studies, Enteral Nutrition, Health Surveys, Humans, Questionnaires, Severity of Illness Index, Time Factors
DOI: 10.1097/MPG.0b013e3181c2c0ef
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 20 Oct 2015 01:02
Last Modified: 27 Oct 2015 02:28

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