Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?

Srinivasan, Srilakshmi, Clements, Judith A., & Batra, Jyotsna (2015) Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer? Critical Reviews in Clinical Laboratory Sciences, 53(1), pp. 29-39.

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Abstract

Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various human complex disorders using candidate gene studies. During the last decade, large scale SNP analysis i.e. genome-wide association studies (GWAS) have provided an agnostic approach to identify possible genetic loci associated with heterogeneous disease such as cancer susceptibility, prognosis of survival or drug response. Further, the advent of new technologies, including microarray based genotyping as well as high throughput next generation sequencing has opened new avenues for SNPs to be used in clinical practice. It is speculated that the utility of SNPs to understand the mechanisms, biology of variable drug response and ultimately treatment individualization based on the individual’s genome composition will be indispensable in the near future. In the current review, we discuss the advantages and disadvantages of the clinical utility of genetic variants in disease risk-prediction, prognosis, clinical outcome and pharmacogenomics. The lessons and challenges for the utility of SNP based biomarkers are also discussed, including the need for additional functional validation studies.

Impact and interest:

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2 citations in Web of Science®

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ID Code: 89239
Item Type: Journal Article
Refereed: Yes
Keywords: SNP, GWAS, Pharmacogenomics, genome, diagnostics, cancer
DOI: 10.3109/10408363.2015.1075469
ISSN: 1549-781X
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Taylor & Francis
Deposited On: 19 Oct 2015 02:43
Last Modified: 14 Apr 2016 00:21

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