The role of IL-17-secreting mast cells in inflammatory joint disease

Kenna, Tony J. & Brown, Matthew A. (2013) The role of IL-17-secreting mast cells in inflammatory joint disease. Nature Reviews Rheumatology, 9(6), pp. 375-379.

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The proinflammatory cytokine IL-17 has an important role in pathogenesis of several inflammatory diseases. In immune-mediated joint diseases, IL-17 can induce secretion of other proinflammatory cytokines such as IL-1, IL-6 and TNF, as well as matrix metalloproteinase enzymes, leading to inflammation, cartilage breakdown, osteoclastogenesis and bone erosion. In animal models of inflammatory arthritis, mice deficient in IL-17 are less susceptible to development of disease. The list of IL-17-secreting cells is rapidly growing, and mast cells have been suggested to be a dominant source of IL-17 in inflammatory joint disease. However, many other innate sources of IL-17 have been described in both inflammatory and autoinflammatory conditions, raising questions as to the role of mast cells in orchestrating joint inflammation. This article will critically assess the contribution of mast cells and other cell types to IL-17 production in the inflammatory milieu associated with inflammatory arthritis, understanding of which could facilitate targeted therapeutic approaches. © 2013 Macmillan Publishers Limited. All rights reserved.

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ID Code: 89287
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :20
Export Date: 21 September 2015
Correspondence Address: Brown, M.A.; University of Queensland Diamantina Institute, Level 4, R Wing, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD 4102, Australia; email:
Keywords: interleukin 17, interleukin 23, STAT3 protein, ankylosing spondylitis, autoimmunity, CD4+ T lymphocyte, CD8+ T lymphocyte, chronic arthritis, cytokine production, cytokine release, genetic association, genetic polymorphism, genetic variability, human, innate immunity, insulin dependent diabetes mellitus, mast cell, mast cell degranulation, natural killer cell, nonhuman, osteoarthritis, pathogenesis, priority journal, protein expression, protein function, protein localization, proteomics, review, rheumatoid arthritis, signal transduction, synovial fluid, Animals, Arthritis, Humans, Interleukin-17, Mast Cells
DOI: 10.1038/nrrheum.2012.205
ISSN: 1759-4790
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Macmillan Publishers
Deposited On: 20 Oct 2015 02:20
Last Modified: 20 Mar 2016 23:55

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