The role of basic nutritional research in pediatric liver disease : an historical perspective

Cleghorn, Geoffrey J. (2009) The role of basic nutritional research in pediatric liver disease : an historical perspective. Journal of Gastroenterology and Hepatology, 24 Suppl, S93-S96.


The advent of liver transplantation for end-stage liver disease (ESLD) in children has necessitated a major rethink in the preoperative preparation and management from simple palliative care to active directed intervention. This is particularly evident in the approach to the nutritional care of these patients with the historical understanding of the nutritional pertubations in ESLD being described from a single pediatric liver transplant center. ESLD in children is a hypermetabolic process adversely affecting nutritional status, metabolic, and non-metabolic body compartments. There is a complex dynamic process affecting metabolic activity within the metabolically active body cell mass, as well as lipid oxidation during fasting and at rest, with other factors operating in conjunction with daily activities. We have proposed that immediately ingested nutrients are a more important source of energy in patients with ESLD than in healthy children, among whom energy may be stored in various body compartments.

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2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 89301
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :2
Export Date: 1 September 2015
Correspondence Address: Cleghorn,
Keywords: potassium, artificial milk, Australia, body weight, energy metabolism, history, human, infant, liver disease, liver transplantation, malnutrition, medical research, nutritional status, nutritional support, palliative therapy, pathophysiology, preschool child, quality of life, review, treatment outcome, Biomedical Research, Child, Preschool, History, 20th Century, History, 21st Century, Humans, Infant Formula, Liver Diseases, Palliative Care
ISSN: 1440-1746
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 23 Oct 2015 00:56
Last Modified: 27 Oct 2015 04:43

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