Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis

Sugnanam, K. K. N., Collins, J. T., Smith, P. K., Connor, F., Lewindon, P., Cleghorn, Geoffrey J., & Withers, G. (2007) Dichotomy of food and inhalant allergen sensitization in eosinophilic esophagitis. Allergy, 62(11), pp. 1257-1260.

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Abstract

Background: Eosinophilic esophagitis (EE) is an emerging condition where patients commonly present with symptoms of gastroesophageal reflux disease and fail to respond adequately to anti-reflux therapy. Food allergy is currently recognized as the main immunological cause of EE; recent evidence suggests an etiological role for inhalant allergens. The presence of EE appears to be associated with other atopic illnesses. Objectives: To report the sensitization profile of both food and inhalant allergens in our EE patient cohort in relation to age, and to profile the prevalence of other allergic conditions in patients with EE. Method: The study prospectively analyzed allergen sensitization profiles using skin prick tests to common food allergens and inhalant allergens in 45 children with EE. Patch testing to common food allergens was performed on 33 patients in the same cohort. Comorbidity of atopic eczema, asthma, allergic rhinitis and anaphylaxis were obtained from patient history. Results: Younger patients with EE showed more IgE and patch sensitization to foods while older patients showed greater IgE sensitization to inhalant allergens. The prevalence of atopic eczema, allergic rhinitis and asthma was significantly increased in our EE cohort compared with the general Australian population. A total of 24% of our cohort of patients with EE had a history of anaphylaxis. Conclusion: In children with EE, the sensitization to inhalant allergens increases with age, particularly after 4 years. Also, specific enquiry about severe food reactions in patients presenting with EE is strongly recommended as it appears this patient group has a high incidence of anaphylaxis. © 2007 The Authors.

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ID Code: 89309
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :42
Export Date: 1 September 2015
CODEN: LLRGD
Correspondence Address: Smith, P.K.; Bond University, Medical School, Robina, QLD 4229, Australia
Keywords: Aeroallergens, Anaphylaxis, Eosinophilic esophagitis, Food allergens, allergen, food allergen, immunoglobulin E, inhalant allergen, unclassified drug, adolescent, allergic rhinitis, article, asthma, atopic dermatitis, atopy, child, clinical article, food allergy, human, infant, patch test, prevalence, priority journal, prospective study, sensitization, skin test, Allergens, Australia, Child, Preschool, Cohort Studies, Comorbidity, Eosinophilia, Eosinophils, Esophagitis, Food Hypersensitivity, Humans, Hypersensitivity, Immediate, Patch Tests, Skin Tests
DOI: 10.1111/j.1398-9995.2007.01454.x
ISSN: 0105-4538
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 22 Oct 2015 23:55
Last Modified: 27 Oct 2015 03:25

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