Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance

Hutmacher, Dietmar Werner, Holzapfel, Boris Michael, De-Juan-Pardo, Elena Maria, Pereira, Brooke Anne, Ellem, Stuart John, Loessner, Daniela, & Risbridger, Gail Petuna (2015) Convergence of regenerative medicine and synthetic biology to develop standardized and validated models of human diseases with clinical relevance. Current Opinion in Biotechnology, 35, pp. 127-132.

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Abstract

In order to progress beyond currently available medical devices and implants, the concept of tissue engineering has moved into the centre of biomedical research worldwide. The aim of this approach is not to replace damaged tissue with an implant or device but rather to prompt the patient's own tissue to enact a regenerative response by using a tissue-engineered construct to assemble new functional and healthy tissue. More recently, it has been suggested that the combination of Synthetic Biology and translational tissue-engineering techniques could enhance the field of personalized medicine, not only from a regenerative medicine perspective, but also to provide frontier technologies for building and transforming the research landscape in the field of in vitro and in vivo disease models.

Impact and interest:

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7 citations in Web of Science®

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ID Code: 89321
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/j.copbio.2015.06.001
ISSN: 0958-1669
Divisions: Current > Schools > School of Biomedical Sciences
Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Crown Copyright 2015
Deposited On: 20 Oct 2015 23:09
Last Modified: 04 May 2016 23:15

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