'Sink or swim': An evaluation of the clinical characteristics of individuals with high bone mass

Gregson, C.L., Steel, S.A., O'Rourke, K.P., Allan, K., Ayuk, J., Bhalla, A., Clunie, G., Crabtree, N., Fogelman, I., Goodby, A., Langman, C.M., Linton, S., Marriott, E., McCloskey, E., Moss, K.E., Palferman, T., Panthakalam, S., Poole, K.E.S., Stone, M.D., Turton, J., Wallis, D., Warburton, S., Wass, J., Duncan, E.L., Brown, M.A., Davey-Smith, G., & Tobias, J.H. (2012) 'Sink or swim': An evaluation of the clinical characteristics of individuals with high bone mass. Osteoporosis International, 23(2), pp. 643-654.

View at publisher (open access)

Abstract

Summary

High bone mineral density on routine dual energy X-ray absorptiometry (DXA) may indicate an underlying skeletal dysplasia. Two hundred fifty-eight individuals with unexplained high bone mass (HBM), 236 relatives (41% with HBM) and 58 spouses were studied. Cases could not float, had mandible enlargement, extra bone, broad frames, larger shoe sizes and increased body mass index (BMI). HBM cases may harbour an underlying genetic disorder.

Introduction

High bone mineral density is a sporadic incidental finding on routine DXA scanning of apparently asymptomatic individuals. Such individuals may have an underlying skeletal dysplasia, as seen in LRP5 mutations. We aimed to characterize unexplained HBM and determine the potential for an underlying skeletal dysplasia.

Methods

Two hundred fifty-eight individuals with unexplained HBM (defined as L1 Z-score ≥ +3.2 plus total hip Z-score ≥ +1.2, or total hip Z-score ≥ +3.2) were recruited from 15 UK centres, by screening 335,115 DXA scans. Unexplained HBM affected 0.181% of DXA scans. Next 236 relatives were recruited of whom 94 (41%) had HBM (defined as L1 Z-score + total hip Z-score ≥ +3.2). Fifty-eight spouses were also recruited together with the unaffected relatives as controls. Phenotypes of cases and controls, obtained from clinical assessment, were compared using random-effects linear and logistic regression models, clustered by family, adjusted for confounders, including age and sex.

Results

Individuals with unexplained HBM had an excess of sinking when swimming (7.11 [3.65, 13.84], p < 0.001; adjusted odds ratio with 95% confidence interval shown), mandible enlargement (4.16 [2.34, 7.39], p < 0.001), extra bone at tendon/ligament insertions (2.07 [1.13, 3.78], p = 0.018) and broad frame (3.55 [2.12, 5.95], p < 0.001). HBM cases also had a larger shoe size (mean difference 0.4 [0.1, 0.7] UK sizes, p = 0.009) and increased BMI (mean difference 2.2 [1.3, 3.1] kg/m 2, p < 0.001).

Conclusion

Individuals with unexplained HBM have an excess of clinical characteristics associated with skeletal dysplasia and their relatives are commonly affected, suggesting many may harbour an underlying genetic disorder affecting bone mass.

Impact and interest:

18 citations in Scopus
Search Google Scholar™
18 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 89341
Item Type: Journal Article
Refereed: Yes
Keywords: Bone mineral density, DXA, High bone mass, Negative buoyancy, Skeletal dysplasia, adult, article, bone density, bone mass, clinical feature, controlled study, female, heredity, human, major clinical study, male, priority journal, Absorptiometry, Photon, Adolescent, Aged, Aged, 80 and over, Anthropometry, Body Mass Index, Bone Diseases, Developmental, Databases, Factual, England, Hip Joint, Humans, Hyperostosis, Lumbar Vertebrae, Mandible, Middle Aged, Prevalence, Swimming, Wales, Young Adult
DOI: 10.1007/s00198-011-1603-4
ISSN: 0937-941X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2011 The Authors
Deposited On: 21 Oct 2015 02:05
Last Modified: 28 Mar 2016 23:37

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page