Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients

Liu, Y., Jiang, L., Cai, Q., Danoy, P., Barnardo, M. C. N. M., Brown, M. A., & Xu, H. (2010) Predominant association of HLA-B*2704 with ankylosing spondylitis in Chinese Han patients. Tissue Antigens, 75(1), pp. 61-64.

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Abstract

The HLA-B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27-subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27-subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case-control association study, and 1545 unrelated, healthy, ethnically matched blood donors were included as controls. The genotyping of B27 and its subtypes was performed using the polymerase chain reaction with sequence specific primers (PCR-SSP). A total of 130 (84.97%) AS patients and 61 (3.95%) healthy controls were B27 positive. Three B27-subtypes, B2704, B2705 and B2710, were further identified, of which both B2704 and B2705 were strongly AS associated. B2710 was only detected in one AS patient and two other healthy controls. Considering only B27-positive cases and controls, a statistically different frequency of B27-subtypes was observed, with an over-representation of B2704 (P = 0.018). B2704 was clearly more strongly associated than B2705 with AS [odds ratio (OR) = 2.4, P = 0.011]. Furthermore, a combined analysis including three previous studies of B27-subtype distributions in Chinese AS cases confirmed the stronger association of B2704 with AS than B*2705 (OR = 2.5, P = 0.00094).

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ID Code: 89386
Item Type: Journal Article
Refereed: Yes
Keywords: Ankylosing spondylitis, Association study, Chinese population, HLA-B27, Subtypes, HLA B antigen, article, blood donor, Chinese, controlled study, disease association, gene frequency, genotype, human, major clinical study, polymerase chain reaction, priority journal, Asian Continental Ancestry Group, Case-Control Studies, China, Genetic Association Studies, Genetic Predisposition to Disease, HLA-B27 Antigen, Humans, Spondylitis, Ankylosing
DOI: 10.1111/j.1399-0039.2009.01379.x
ISSN: 0001-2815
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 John Wiley & Sons A/S
Deposited On: 22 Oct 2015 01:11
Last Modified: 19 Aug 2016 05:08

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