Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in finns

Pointon, J.J., Chapman, K., Harvey, D., Sims, A.M., Bradbury, L., Laiho, K., Kauppi, M., Kaarela, K., Tuomilehto, J., Brown, M.A., & Wordsworth, B.P. (2008) Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in finns. Journal of Rheumatology, 35(8), pp. 1609-1612.

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To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).


A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.


In the Finnish study the CD74-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.


CD14 and TLR4 showed an association with AS in the Finns only.

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5 citations in Web of Science®

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ID Code: 89414
Item Type: Journal Article
Refereed: Yes
Keywords: Ankylosing spondylitis, Genetic studies, Immune system, CD14 antigen, toll like receptor 4, article, Finland, genetic association, genetic marker, genetic polymorphism, genetic variability, haplotype, human, priority journal, promoter region, United Kingdom, Antigens, CD14, Case-Control Studies, Cohort Studies, Female, Genetic Predisposition to Disease, Great Britain, Humans, Male, Odds Ratio, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing, Toll-Like Receptor 4
ISSN: 0315-162X
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 23 Oct 2015 03:26
Last Modified: 26 Feb 2016 03:53

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