Evidence-based recommendations for the monitoring and treatment of ankylosing spondylitis: Results from the Australian 3E initiative in rheumatology

Kain, T., Zochling, J., Taylor, A., Manolios, N., Smith, M. D., Reed, M. D., Brown, Matthew A., & Schachna, L. (2008) Evidence-based recommendations for the monitoring and treatment of ankylosing spondylitis: Results from the Australian 3E initiative in rheumatology. International Journal of Rheumatic Diseases, 11(1), pp. 45-49.

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Aim: To develop a set of Australian recommendations for the monitoring and treatment of ankylosing spondylitis (AS) through systematic literature review combined with the opinion of practicing rheumatologists.

Methods: A set of eight questions, four in each domain of monitoring and treatment, were formulated by voting and the Delphi method. The results of a systematic literature review addressing each question were presented to the 23 participants of the Australian 3E meeting. All participants were clinical rheumatologists experienced in the daily management of AS.

Results: After three rounds of breakout sessions to discuss the findings of the literature review, a set of recommendations was finalized after discussion and voting. The category of evidence and strength of recommendation were determined for each proposal. The level of agreement among participants was excellent (mean 84%, range 64-100%).

Conclusions: The 12 recommendations developed from evidence and expert opinion provide guidance for the daily management of AS patients. For most recommendations, we found a paucity of supportive evidence in the literature highlighting the need for additional clinical studies.

Impact and interest:

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ID Code: 89417
Item Type: Journal Article
Refereed: Yes
Keywords: Ankylosing spondylitis, Australian, Monitoring, Recommendations, Treatment, bisphosphonic acid derivative, corticosteroid, nonsteroid antiinflammatory agent, proton pump inhibitor, tumor necrosis factor alpha inhibitor, article, Australia, clinical practice, clinical trial, consensus development, Delphi study, drug choice, drug efficacy, drug megadose, drug response, evidence based medicine, gastrointestinal symptom, human, kinesiotherapy, medical specialist, osteoporosis, patient compliance, patient monitoring, physiotherapy, practice guideline, priority journal, stretching exercise, systematic review
DOI: 10.1111/j.1756-185X.2008.00329.x
ISSN: 1756-1841
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2008 Asia Pacific League of Associations for Rheumatology
Deposited On: 23 Oct 2015 01:20
Last Modified: 26 Jun 2017 02:02

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