'Free' surfactant in gastric aspirates and bronchoalveolar lavage in children with and without reflux oesophagitis

Chang, A. B., Hills, Y. C., Cox, N. C., Cleghorn, Geoffrey J., Valery, P. C., Lewindon, P. J., Ee, L. C., Withers, G. D., Beem, C., & Hills, B. A. (2006) 'Free' surfactant in gastric aspirates and bronchoalveolar lavage in children with and without reflux oesophagitis. Internal Medicine Journal, 36(4), pp. 226-230.

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Aim: Dipalmitoylphosphatidycholine (DPPC) is the characteristic and main constituent of surfactant. Adsorption of surfactant to epithelial surfaces may be important in the masking of receptors. The aims of the study were to (i) compare the quantity of free DPPC in the airways and gastric aspirates of children with gastroesophageal reflux disease (GORD) to those without and (ii) describe the association between free DPPC levels with airway cellular profile and capsaicin cough sensitivity. Methods: Children aged <14 years were defined as 'coughers' if a history of cough in association with their GORD symptoms was elicited before gastric aspirates and nonbronchoscopic bronchoalveolar lavage (BAL) were obtained during elective flexible upper gastrointestinal endoscopy. GORD was defined as histological presence of reflux oesophagitis. Spirometry and capsaicin cough-sensitivity test was carried out in children aged >6 years before the endoscopy. Results: Median age of the 68 children was 9 years (interquartile range (IQR) 7.2). Median DPPC level in BAL of children with cough (72.7 μg/mL) was similar to noncoughers (88.5). There was also no significant difference in DPPC levels in both BAL and gastric aspirates of children classified according to presence of GORD. There was no correlation between DPPC levels and cellular counts or capsaicin cough-sensitivity outcome measures. Conclusion: We conclude that free DPPC levels in the airways and gastric aspirate is not influenced by presence of cough or GORD defined by histological presence of reflux oesophagitis. Whether quantification of adsorbed surfactant differs in these groups remain unknown. Free DPPC is unlikely to have a role in masking of airway receptors. © 2006 Royal Australasian College of Physicians.

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ID Code: 89439
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :2
Export Date: 1 September 2015
Correspondence Address: Chang, A.B.; Department of Respiratory Medicine, Royal Children's Hospital, Herston, QLD 4029, Australia; email: annechang@ausdoctors.net
Keywords: Children, Cough, Gastroesophageal reflux, Oesophagitis, Surfactant, capsaicin, dipalmitoylphosphatidylcholine, adolescent, article, cell count, child, controlled study, coughing, ear reconstruction, female, gastrointestinal endoscopy, histology, human, infant, lung lavage, major clinical study, male, neutrophilia, outcome assessment, priority journal, reflux esophagitis, respiratory system, sensitivity analysis, spirometry, stomach juice, stomach suction, 1, 2-Dipalmitoylphosphatidylcholine, Bronchoalveolar Lavage Fluid, Child, Preschool, Esophagitis, Gastric Juice, H(+)-K(+)-Exchanging ATPase, Humans, Pulmonary Surfactants
DOI: 10.1111/j.1445-5994.2006.01041.x
ISSN: 1444-0903
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 25 Oct 2015 23:56
Last Modified: 28 Oct 2015 02:45

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