Effect of an estrogen receptor-α intron 4 polymorphism on fat mass in 11-year-old children
Tobias, J. H., Steer, C. D., Vilariňo-Güell, C., & Brown, M. A. (2007) Effect of an estrogen receptor-α intron 4 polymorphism on fat mass in 11-year-old children. Journal of Clinical Endocrinology and Metabolism, 92(6), pp. 2286-2291.
in the ESR1 gene encoding estrogen receptor (ER)-α may be associated with fat mass in adults. Objectives: The objective of the study was to establish whether ESR1 polymorphisms influence fat mass in childhood. Design: This was a cross-sectional analysis after genotyping of rs9340799, rs2234693, and rs7757956 ESR1 polymorphisms.
The Avon Longitudinal Study of Parents and Children (ALSPAC) was a population-based prospective study.
Participants included 3097 11-yr-old children with results for ESR1 genotyping, puberty measures, and dual-energy x-ray absorptiometry results.
Relationships between ESR1 polymorphisms and indices of body composition were measured. Results: The rs7757956 polymorphism was associated with fat mass (P = 0.002). Total body fat mass (adjusted for height) was reduced by 6% in children with TA/AA genotypes, and risk of being overweight (≥85th centile of fat mass) was decreased by 20%. This genetic effect appeared to interact with puberty in girls (P = 0.05 for interaction): in those with the TT genotype, total body fat mass (adjusted for height) was 18% higher in Tanner stages 3-5 vs. stages 1-2; the equivalent difference was 7% in those with TA/AA genotypes. Furthermore, the risk of being overweight was 36% lower in girls with TA/AA genotypes in Tanner stages 3-5, but no reduction was seen in those in stages 1-2. Neither rs9340799 nor rs2234693 polymorphisms were associated with body composition measures.
Fat mass in 11-yr-old children was related to the rs7757956 ESR1 polymorphism. This association was strongest in girls in more advanced puberty, in whom the risk of being overweight was reduced by 36% in those with the TA/AA genotype.
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|Item Type:||Journal Article|
|Additional Information:||Cited By :13 Export Date: 21 September 2015 CODEN: JCEMA Correspondence Address: Tobias, J.H.; Rheumatology Unit, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom; email: firstname.lastname@example.org|
|Keywords:||estrogen receptor alpha, fat, article, body composition, body fat, cross-sectional study, dual energy X ray absorptiometry, female, genetic polymorphism, genotype, human, intron, male, priority journal, puberty, school child, Adipose Tissue, Body Height, Child, Cross-Sectional Studies, Densitometry, X-Ray, Genetic Predisposition to Disease, Humans, Introns, Longitudinal Studies, Obesity, Polymorphism, Genetic, Risk Factors|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright © 2007 Endocrine Society|
|Deposited On:||25 Oct 2015 23:11|
|Last Modified:||19 Aug 2016 01:27|
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