Non-B27 MHC associations of ankylosing spondylitis

Sims, A. M., Barnardo, M., Herzberg, I., Bradbury, L., Calin, A., Wordsworth, B. P., Darke, C., & Brown, M. A. (2007) Non-B27 MHC associations of ankylosing spondylitis. Genes and Immunity, 8(2), pp. 115-123.

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Abstract

Ankylosing spondylitis (AS) has been associated with human leukocyte antigen (HLA)-B27 for over 30 years; however, the mechanism of action has remained elusive. Although many studies have reported associations between AS and other genes in the major histocompatibility complex (MHC) in AS, no conclusive results have emerged. To investigate the contribution of non-B27 MHC genes to AS, a large cohort of AS families and controls were B27 typed and genotyped across the region. Interrogation of the data identified a region of 270kb, lying from 31952649 to 32221738 base pairs from the p-telomere of chromosome 6 and containing 23 genes, which is likely to include genes involved with susceptibility to AS.

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ID Code: 89471
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :31
Export Date: 21 September 2015
CODEN: GEIMA
Correspondence Address: Brown, M.A.; Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia
Keywords: HLA B27 antigen, ankylosing spondylitis, article, base pairing, chromosome 6, controlled study, data analysis, family study, gene locus, genetic association, genetic susceptibility, genotype, HLA typing, human, major clinical study, major histocompatibility complex, pathophysiology, priority journal, telomere, Case-Control Studies, Chromosomes, Human, Pair 6, DNA Primers, England, Genetic Predisposition to Disease, Haplotypes, Humans, Polymerase Chain Reaction, Spondylitis, Ankylosing
DOI: 10.1038/sj.gene.6364362
ISSN: 1466-4879
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2007 Nature Publishing Group
Deposited On: 25 Oct 2015 22:56
Last Modified: 19 Aug 2016 01:53

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