Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton

Koay, M. A. & Brown, Matthew A. (2005) Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton. Trends in Molecular Medicine, 11(3), pp. 129-137.

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Osteoporosis is a common, increasingly prevalent and potentially debilitating condition of men and women. Genetic factors are major determinants of bone mass and the risk of fracture, but few genes have been definitively demonstrated to be involved. The identification of these factors will provide novel insights into the processes of bone formation and loss and thus the pathogenesis of osteoporosis, enabling the rational development of novel therapies. In this article, we present the extensive genetic and functional data indicating that the LRP5 gene and the Wnt signalling pathway are key players in bone formation and the risk of osteoporosis, and that LRP5 signalling is essential for normal morphology, developmental processes and bone health.

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ID Code: 89482
Item Type: Journal Article
Refereed: Yes
Keywords: isoprotein, low density lipoprotein receptor related protein 5, Wnt protein, Albers Schoenberg disease, bone density, bone development, bone disease, bone mass, bone structure, carcinoma, familial disease, gene function, genetic disorder, genetic polymorphism, insulin dependent diabetes mellitus, nonhuman, ossification, osteoporosis, pathogenesis, pathology, phenotype, protein expression, protein function, protein structure, review, risk factor, signal transduction, skeleton, vitreoretinopathy, Animals, Bone and Bones, Humans, Intercellular Signaling Peptides and Proteins, LDL-Receptor Related Proteins, Models, Biological, Polymorphism, Genetic, Wnt Proteins
DOI: 10.1016/j.molmed.2005.01.004
ISSN: 1471-4914
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Elsevier Ltd.
Deposited On: 25 Oct 2015 23:32
Last Modified: 26 Oct 2015 00:42

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