Acute liver failure in children : a regional experience

Ee, L. C., Shepherd, R. W., Cleghorn, Geoffrey J., Lewindon, P. J., Fawcett, J., Strong, R. W., & Lynch, S. V. (2003) Acute liver failure in children : a regional experience. Journal of Paediatrics and Child Health, 39(2), pp. 107-110.

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Objective: To review the outcome of acute liver failure (ALF) and the effect of liver transplantation in children in Australia. Methodology: A retrospective review was conducted of all paediatric patients referred with acute liver failure between 1985 and 2000 to the Queensland Liver Transplant Service, a paediatric liver transplant centre based at the Royal Children's Hospital, Brisbane, that is one of three paediatric transplant centres in Australia. Results: Twenty-six patients were referred with ALF. Four patients did not require transplantation and recovered with medical therapy while two were excluded because of irreversible neurological changes and died. Of the 20 patients considered for transplant, three refused for social and/or religious reasons, with 17 patients listed for transplantation. One patient recovered spontaneously and one died before receiving a transplant. There were 15 transplants of which 40% (6/15) were < 2 years old. Sixty-seven per cent (10/15) survived > 1 month after transplantation. Forty per cent (6/15) survived more than 6 months after transplant. There were only four long term survivors after transplant for ALF (27%). Overall, 27% (6/22) of patients referred with ALF survived. Of the 16 patients that died, 44% (7/16) were from neurological causes. Most of these were from cerebral oedema but two patients transplanted for valproate hepatotoxicity died from neurological disease despite good graft function. Conclusions: Irreversible neurological disease remains a major cause of death in children with ALF. We recommend better patient selection and early referral and transfer to a transplant centre before onset of irreversible neurological disease to optimize outcome of children transplanted for ALF.

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17 citations in Scopus
13 citations in Web of Science®
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ID Code: 89505
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :15
Export Date: 1 September 2015
Correspondence Address: Ee, L.C.; Department of Gastroenterology, Royal Children's Hospital, Herston Road, Brisbane, QLD 4029, Australia; email:
Keywords: Liver failure, Liver transplant, Outcome, Paediatric, carbamazepine, cotrimoxazole, methotrexate, valproic acid, article, brain edema, cause of death, child, clinical article, human, infant, liver transplantation, mortality, outcomes research, priority journal, Age Distribution, Child, Preschool, Female, Graft Rejection, Graft Survival, Humans, Incidence, Liver Failure, Acute, Male, Prognosis, Queensland, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Distribution, Survival Analysis
DOI: 10.1046/j.1440-1754.2003.00087.x
ISSN: 1034-4810
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 04 Nov 2015 01:27
Last Modified: 26 Jun 2017 03:01

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