Successful topical tacrolimus (FK506) therapy in a child with pyoderma gangrenosum

Kimble, Roy M., Tickler, Aenaone K., Nicholls, Victoria S., & Cleghorn, Geoffrey J. (2002) Successful topical tacrolimus (FK506) therapy in a child with pyoderma gangrenosum. Journal of Pediatric Gastroenterology and Nutrition, 34(5), pp. 555-557.

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Abstract

The inflammatory skin disease pyoderma gangrenosum is characterized by destructive ulceration, typically occurring on the calves and thighs and less commonly on the buttocks and face. Lesions vary in size and may be multiple, often rapidly ulcerating to form deep painful wounds. Ulcers characteristically have ragged purple edges that overhang. In many patients a concomitant condition can be identified such as inflammatory bowel disease, rheumatoid arthritis, chronic autoimmune hepatitis, and various hematologic and solid tumours (1,2). Treatment of these ulcers in the past has been disappointing. The large lesions usually run a chronic course and heal very slowly, with traditional dressings often in combination with systemic steroids or immunosuppressants. Since 1998, a small number of case have been reported of adults with pyoderma gangrenosum whose lesions heal with the use of topical tacrolimus (FK506) (2–4). We report, to the best of our knowledge, the first successful treatment of a child with pyoderma gangrenosum using topical tacrolimus.

Impact and interest:

19 citations in Scopus
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12 citations in Web of Science®

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ID Code: 89509
Item Type: Journal Article
Refereed: Yes
Keywords: budesonide, chlorhexidine, cyclosporin, hydrocortisone, mesalazine, prednisolone, steroid, sulfadiazine silver, tacrolimus, adolescent, article, case report, clinical feature, diarrhea, headache, human, hypertension, male, priority journal, pyoderma gangrenosum, Administration, Topical, Colitis, Ulcerative, Humans, Immunosuppressive Agents, Treatment Outcome
DOI: 10.1097/00005176-200205000-00015
ISSN: 0277-2116
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 04 Nov 2015 02:18
Last Modified: 04 Nov 2015 22:13

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