Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues

Roulis, Eileen, Bachmann, Nathan L., Myers, Garry S.A., Huston, Wilhelmina, Summersgill, James, Hudson, Alan, Dreses-Werringloer, Ute, Polkinghorne, Adam, & Timms, Peter (2015) Comparative genomic analysis of human Chlamydia pneumoniae isolates from respiratory, brain and cardiac tissues. Genomics, 106(6), pp. 373-383.

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Abstract

Chlamydia pneumoniae is an obligate intracellular bacterium implicated in a wide range of human diseases including atherosclerosis and Alzheimer's disease. Efforts to understand the relationships between C. pneumoniae detected in these diseases have been hindered by the availability of sequence data for non-respiratory strains. In this study, we sequenced the whole genomes for C. pneumoniae isolates from atherosclerosis and Alzheimer's disease, and compared these to previously published C. pneumoniae genomes. Phylogenetic analyses of these new C. pneumoniae strains indicate two sub-groups within human C. pneumoniae, and suggest that both recombination and mutation events have driven the evolution of human C. pneumoniae. Further fine-detailed analyses of these new C. pneumoniae sequences show several genetically variable loci. This suggests that similar strains of C. pneumoniae are found in the brain, lungs and cardiovascular system and that only minor genetic differences may contribute to the adaptation of particular strains in human disease.

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ID Code: 89523
Item Type: Journal Article
Refereed: Yes
Keywords: Chlamydia pneumoniae, comparative genomics, evolution, recombination, cardiovascular, Alzheimer's disease
DOI: 10.1016/j.ygeno.2015.09.008
ISSN: 0888-7543
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2015 Published by Elsevier Inc.
Deposited On: 27 Oct 2015 01:57
Last Modified: 16 May 2016 03:25

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