A review of the MHC genetics of rheumatoid arthritis

Newton, J. L., Harney, S. M. J., Wordsworth, B. P., & Brown, M. A. (2004) A review of the MHC genetics of rheumatoid arthritis. Genes and Immunity, 5(3), pp. 151-157.

View at publisher


Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design. © 2004 Nature Publishing Group All rights reserved.

Impact and interest:

156 citations in Scopus
Search Google Scholar™
144 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 89540
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :145
Export Date: 21 September 2015
Correspondence Address: Brown, M.A.; Inst. of Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, United Kingdom; email: mbrown@well.ox.ac.uk
Keywords: Genetics, Major histocompatibility complex, Rheumatoid arthritis, HLA DQB1 antigen, HLA DR antigen, major histocompatibility antigen, major histocompatibility antigen class 3, tumor necrosis factor, experimental design, gene linkage disequilibrium, genetic association, genetic susceptibility, heritability, human, priority journal, review, Arthritis, Rheumatoid, Genetic Predisposition to Disease, HLA-DR Antigens, Humans
DOI: 10.1038/sj.gene.6364045
ISSN: 1466-4879
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Nature Publishing Group
Deposited On: 27 Oct 2015 00:43
Last Modified: 27 Oct 2015 00:43

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page