A review of the MHC genetics of rheumatoid arthritis

Newton, J. L., Harney, S. M. J., Wordsworth, B. P., & Brown, M. A. (2004) A review of the MHC genetics of rheumatoid arthritis. Genes and Immunity, 5(3), pp. 151-157.

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Abstract

Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design. © 2004 Nature Publishing Group All rights reserved.

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ID Code: 89540
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :145
Export Date: 21 September 2015
CODEN: GEIMA
Correspondence Address: Brown, M.A.; Inst. of Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, United Kingdom; email: mbrown@well.ox.ac.uk
Keywords: Genetics, Major histocompatibility complex, Rheumatoid arthritis, HLA DQB1 antigen, HLA DR antigen, major histocompatibility antigen, major histocompatibility antigen class 3, tumor necrosis factor, experimental design, gene linkage disequilibrium, genetic association, genetic susceptibility, heritability, human, priority journal, review, Arthritis, Rheumatoid, Genetic Predisposition to Disease, HLA-DR Antigens, Humans
DOI: 10.1038/sj.gene.6364045
ISSN: 1466-4879
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Nature Publishing Group
Deposited On: 27 Oct 2015 00:43
Last Modified: 27 Oct 2015 00:43

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