Osteoclast formation from circulating precursors in osteoporosis

Jevon, M., Hirayama, T., Brown, M. A., Wass, J. A. H., Sabokbar, A., Ostelere, S., & Athanasou, N. A. (2003) Osteoclast formation from circulating precursors in osteoporosis. Scandinavian Journal of Rheumatology, 32(2), pp. 95-100.

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Abstract

Objective:

An imbalance between bone formation and bone resorption is thought to underlie the pathogenesis of reduced bone mass in osteoporosis. Bone resorption is carried out by osteoclasts, which are formed from marrow-derived cells that circulate in the monocyte fraction. Ihe aim of this study was to determine the role of osteoclast formation in the pathogenesis of bone loss in osteoporosis.

Methods:

The proportion of circulating osteoclast precursors and their relative sensitivity to the osteoclastogenic effects of M-CSF, 1,25(OH)2D3 and RANKL were assessed in primary osteoporosis patients and normal controls.

Results:

Although there was no difference in the number of circulating osteoclast precursors in osteoporosis patients and normal controls, osteoclasts formed from osteoporosis patients exhibited substantially increased resorptive activity relative to normal controls. Although no increased sensitivity to the osteoclastogenic effects of 1,25(OH)2D3 or M-CSF was noted, increased bone resorption was found in osteoporosis peripheral blood mononuclear cell (PBMC) cultures to which these factors were added. Conclusion: Our findings suggest that osteoclast functional activity rather than formation is increased in primary involutional osteoporosis and that dexamethasone acts to increase osteoclast formation.

Impact and interest:

16 citations in Scopus
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15 citations in Web of Science®

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ID Code: 89545
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :14
Export Date: 21 September 2015
CODEN: SJRHA
Correspondence Address: Athanasou, N.A.; Department of Pathology, Nuffield Orthopaedic Centre, Headington, Oxford OX3 7LD, United Kingdom; email: nick.athanasou@ndos.ox.ac.uk
Keywords: Bone resorption, Monocyte, Osteoclast, Osteoporosis, calcitriol, colony stimulating factor 1, dexamethasone, osteoclast differentiation factor, adult, aged, article, bone marrow cell, bone mass, clinical article, controlled study, drug effect, female, human, human cell, mononuclear cell, ossification, osteolysis, pathogenesis, priority journal, stem cell, Biological Markers, Carrier Proteins, Cells, Cultured, Coculture Techniques, Dose-Response Relationship, Drug, Humans, Immunoenzyme Techniques, Leukocytes, Mononuclear, Macrophage Colony-Stimulating Factor, Membrane Glycoproteins, Middle Aged, Osteoclasts, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Stem Cells
DOI: 10.1080/03009740310000102
ISSN: 0300-9742
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Taylor & Francis
Deposited On: 27 Oct 2015 01:04
Last Modified: 27 Oct 2015 01:04

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