Interleukin 10 polymorphisms in ankylosing spondylitis

Goedecke, V., Crane, A. M., Jaakkola, E., Kaluza, W., Laiho, K., Weeks, D. E., Wilson, J., Kauppi, M., Kaarela, K., Tuomilehto, J., Wordsworth, B. P., & Brown, M. A. (2003) Interleukin 10 polymorphisms in ankylosing spondylitis. Genes and Immunity, 4(1), pp. 74-76.

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Genetic polymorphisms of the IL10 promoter region have been implicated in many autoimmune diseases, including seronegative spondyloarthropathies. We studied three SNPs (IL10-1087,-824, and -597) and two microsafellites(IL10R and IL10G) lying within the promoter region of IL10 for association with susceptibility to and clinical manifestations of ankylosing spondylitis (AS), a common form of spondyloarthritis. Four hundred and sixty-eight individuals from 182 Finnish families affected with AS were studied. No association between individual IL10 promoter region polymorphisms or marker haplotype was observed with susceptibility to AS, but weak association was noted between the IL10-597 and -824 SNPs and age of disease onset (P= 0.01 for each SNP). The IL10.G4 allele was associated with BASFI (corrected for disease duration) (P= 0.03). We conclude that IL10 promoter polymorphisms have no significant effect on susceptibility to AS, but may play a minor role in determining age of disease onset and disease severity. © 2003 Nature Publishing Group All rights reserved.

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23 citations in Scopus
17 citations in Web of Science®
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ID Code: 89547
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :22
Export Date: 21 September 2015
Correspondence Address: Brown, M.A.; Spondyloarthritis/Bone Dis. Res. Grp, Wellcome Trust Ctr. for Hum. Genet., Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom; email:
Keywords: Ankylosing spondylitis, Association, Genetics, IL10, interleukin 10, microsatellite DNA, allele, article, clinical feature, disease duration, disease severity, Finland, genetic association, genetic polymorphism, haplotype, human, major clinical study, microsatellite marker, onset age, priority journal, promoter region, rating scale, single nucleotide polymorphism, Alleles, Humans, Interleukin-10, Microsatellite Repeats, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Spondylitis, Ankylosing
DOI: 10.1038/sj.gene.6363930
ISSN: 1466-4879
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Publishing Group
Deposited On: 27 Oct 2015 00:50
Last Modified: 26 Jun 2017 03:01

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