Susceptibility to ankylosing spondylitis

Carter, N., Williamson, L., Kennedy, L. G., Brown, M. A., & Wordsworth, B. P. (2000) Susceptibility to ankylosing spondylitis. Rheumatology, 39(4), p. 445.

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Sir The association between HLA‐B27 (B27) and ankylosing spondylitis (AS) has been known for 25 yr. Familial aggregation in AS is well established, and first‐degree relatives of AS patients have been shown to be at increased risk of developing the disease. The recurrence risk in siblings of AS patients is quite uncertain, previous studies have variously reported recurrence risks between 6.9 and 27% [1, 2]. Accurate knowledge of the sibling recurrence risk is important both to advise families of the likelihood of disease recurrence, and in genetic statistical analyses utilizing Risch's recurrence risk ratio [3]. This study was designed to determine the risk of developing AS in siblings and to determine the role of the major histocompatibility complex in familial recurrence of AS....

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ID Code: 89555
Item Type: Journal Article
Refereed: Yes
Keywords: adult, ankylosing spondylitis, disease predisposition, female, HLA system, human, letter, major clinical study, male, priority journal, Aged, HLA-B27 Antigen, Humans, Major Histocompatibility Complex, Middle Aged, Recurrence, Risk Assessment, Spondylitis, Ankylosing
DOI: 10.1093/rheumatology/39.4.445
ISSN: 1462-0324
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2000 Oxford University Press
Deposited On: 27 Oct 2015 00:36
Last Modified: 27 Oct 2015 00:36

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