Energy expenditure and the body cell mass in cystic fibrosis

Shepherd, R. W., Greer, R. M., McNaughton, S. A., Wotton, M., & Cleghorn, G. J. (2001) Energy expenditure and the body cell mass in cystic fibrosis. Nutrition, 17(1), pp. 22-25.

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Poor nutritional status in patients with cystic fibrosis (CF) is associated with severe lung disease, and possible causative factors include inadequate intake, malabsorption, and increased energy requirements. Body cell mass (which can be quantified by measurement of total body potassium) provides an ideal standard for measurements of energy expenditure. The aim of this study was to compare resting energy expenditure (REE) in patients with CF with both predicted values and age-matched healthy children and to determine whether REE was related to either nutritional status or pulmonary function. REE was measured by indirect calorimetry and body cell mass by scanning with total body potassium in 30 patients with CF (12 male, mean age = 13.07 ± 0.55 y) and 18 healthy children (six male, mean age = 12.56 ± 1.25 y). Nutritional status was expressed as a percentage of predicted total body potassium. Lung function was measured in the CF group by spirometry and expressed as the percentage of predicted forced expiratory volume in 1 s. Mean REE was significantly increased in the patients with CF compared with healthy children (119.3 ± 3.1% predicted versus 103.6 ± 5% predicted, P < 0.001) and, using multiple regression techniques, REE for total body potassium was significantly increased in patients with CF (P = 0.0001). There was no relation between REE and nutritional status or pulmonary disease status in the CF group. In conclusion, REE is increased in children and adolescents with CF but is not directly related to nutritional status or pulmonary disease.

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ID Code: 89603
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :22 Export Date: 1 September 2015 CODEN: NUTRE Correspondence Address: Shepherd, R.W.; Dept. Paediatrics and Child Health, Royal Children's Hospital, Herston, QLD 4029, Australia; email:
Keywords: Body-cell mass, Cystic fibrosis, Pulmonary function, Resting energy expenditure, Total body potassium, potassium, adolescent, adult, age, article, body composition, body mass, caloric intake, calorimetry, child, clinical article, controlled study, disease severity, energy expenditure, female, human, inner cell mass, lung disease, lung function, malabsorption, male, measurement, multiple regression, nutritional status, priority journal, rest, spirometry, standard, Basal Metabolism, Case-Control Studies, Child Nutrition Disorders, Cross-Sectional Studies, Energy Metabolism, Humans, Prospective Studies, Respiratory Function Tests
DOI: 10.1016/S0899-9007(00)00470-6
ISSN: 0899-9007
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Copyright Owner: Copyright © 2001 Elsevier Science Inc.
Deposited On: 28 Oct 2015 00:03
Last Modified: 28 Oct 2015 00:03

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