Malnutrition, gastroenteritis and trypsinogen concentration in hospitalised aboriginal children

Briars, G. L., Thornton, S. J., Forrest, Y., Ehrlich, J., Shepherd, R. W., & Cleghorn, G. J. (1998) Malnutrition, gastroenteritis and trypsinogen concentration in hospitalised aboriginal children. Journal of Paediatrics and Child Health, 34(1), pp. 69-73.

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Objective: To explore relationships between malnutrition and pancreatic damage in hospitalised aboriginal children.

Methods: Immunoreactive trypsinogen (IRT) concentrations were measured in two populations of hospitalised aboriginal children in Australia; 472 children aged 0-3 years, in Alice Springs (Northern Territory); and 187 children aged 0-16 years in Mount Isa (Queensland). Correlation of whole blood IRT with height and weight z-scores, four-site skinfold thickness and upper arm circumference was sought.

Results: In Mount Isa, the geometric mean IRT concentration rose with decreasing weight z-score. The IRT concentration was otherwise unrelated to nutritional indices. Sixty percent of the 39 Mount Isa patients with gastroenteritis and 24.5% of the 358 Alice Springs patients with gastroenteritis had an IRT concentration in the upper quartile for their population, compared with 16% for patients with other diagnoses in both populations.

Conclusions: A high IRT concentration in patients with low weight z-scores is a confounding effect of gastroenteritis, and may result from subclinical pancreatic disease in gastroenteritis.

Impact and interest:

2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 89613
Item Type: Journal Article
Refereed: Yes
Keywords: Aboriginal, Gastroenteritis, Malnutrition, Trypsinogen, adolescent, article, child, diagnostic accuracy, disease association, hospitalization, human, immunocompetent cell, infant, major clinical study, mortality, pancreas injury, priority journal, skinfold thickness, Analysis of Variance, Anthropometry, Australia, Child Nutrition Disorders, Child, Preschool, Humans, Infant Nutrition Disorders, Oceanic Ancestry Group, Pancreatic Diseases
DOI: 10.1046/j.1440-1754.1998.00157.x
ISSN: 1034-4810
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1998 Wiley-Blackwell Publishing Ltd.
Deposited On: 28 Oct 2015 02:45
Last Modified: 28 Oct 2015 02:45

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