Determination of the effect of JO146, a CtHtrA inhibitor, on the chlamydial developmental cycle and persistence

Ong, Vanissa A. (2015) Determination of the effect of JO146, a CtHtrA inhibitor, on the chlamydial developmental cycle and persistence. PhD thesis, Queensland University of Technology.

[img] Vanissa Ong Thesis (PDF 5MB)
Administrators only until 3 November 2016


The role of Chlamydia trachomatis HtrA (CtHtrA) for the growth and pathogenesis of this organism is presented. Inhibition of CtHtrA led to loss of infectious progeny in Chlamydia, particularly during heat stress or recovery from penicillin persistence. Isolation of CtHtrA inhibitor resistant mutants identified positive selection for mutants in fatty acid related pathways. Importantly, HtrA inhibition was effective against clinical isolates of C. trachomatis. Thus the findings combined indicate that CtHtrA is an important chlamydial growth factor that has the potential to be targeted for the development of anti-chlamydial drugs in the future.

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ID Code: 89931
Item Type: QUT Thesis (PhD)
Supervisor: Huston, Willa & Beagley, Kenneth
Additional Information: The Faculty has embargoed this thesis until 3rd November 2016.
Keywords: Chlamydia trachomatis, intracellular pathogen, clinical isolate, HtrA, protease, inhibitor, mutants, developmental cycle
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 16 Feb 2016 02:36
Last Modified: 16 Feb 2016 02:36

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