Osmolality electrolyte and carbohydrate type and oral rehydration solutions: A controlled study to compare the efficacy of two commercially available solutions (osmolalities 240 mmol/L and 340 mmol/L)

Wall, C. R., Shepherd, R. W., Patrick, M., Chin, S., & Cleghorn, Geoffrey J. (1993) Osmolality electrolyte and carbohydrate type and oral rehydration solutions: A controlled study to compare the efficacy of two commercially available solutions (osmolalities 240 mmol/L and 340 mmol/L). Journal of Diarrhoeal Diseases Research, 11(4), pp. 222-226.

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Abstract

An open-label, inpatient study was undertaken to compare the efficacy of two oral rehydration solutions (ORS) given randomly to children aged 1-10 years who had acute gastroenteritis with mild or moderate dehydration (n = 45). One solution contained 60 mmol/L sodium and 1.8% glucose, total osmolality 240 mosm/l (gastrolyte, Rhone-poulenc, Rorer) and the other contained 26 mmol/l sodium, 2.7% glucose and 3.6% sucrose, total osmolality 340 mOsm/l (Glucolyte, Gilseal). Analysis of data indicated that Gastrolyte therapy resulted in significantly fewer episodes and volume of vomiting over all time periods in comparison to Glucolyte and significantly less stool volume during the first 8 h and in the 0-24 h period. The differences between treatments in degree of dehydration at each follow-up period, duration of diarrhea, and duration of hospital stay were not significant. No adverse drug reactions occurred. Six patients received intravenous rehydration treatment and were considered treatment failures. We conclude that oral rehydration therapy is safe and efficacious in the management of dehydration in acute diarrhoea and that the lower osmolar rehydration solution has clinically marginal advantages.

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ID Code: 90012
Item Type: Journal Article
Refereed: No
Additional Information: Cited By :2
Export Date: 1 September 2015
CODEN: JDDRE
Correspondence Address: Gleghorn, G.; Children's Nutrition Research Centre, Department of Child Health, University of Queensland, Herston, QLD 4029, Australia
Keywords: acute gastroenteritis, dehydration, oral rehydration solution, osmolality, stool volume, vomiting, glucolyte, unclassified drug, article, child, clinical trial, controlled clinical trial, controlled study, drug efficacy, gastroenteritis, human, infant, major clinical study, oral drug administration, Acute Disease, Child, Preschool, Female, Fluid Therapy, Glucose, Humans, Male, Osmolar Concentration, Rehydration Solutions, Sodium, Sucrose, Time Factors, Treatment Outcome
ISSN: 0253-8768
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
Deposited On: 13 Nov 2015 00:32
Last Modified: 13 Nov 2015 00:32

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