Serum immunoglobulin G directed against porcine trypsin in the serum of cystic fibrosis children receiving porcine pancreatic enzyme supplements
Quirk, P., Greer, R., Shepherd, R., & Cleghorn, Geoffrey J. (1993) Serum immunoglobulin G directed against porcine trypsin in the serum of cystic fibrosis children receiving porcine pancreatic enzyme supplements. Journal of Paediatrics and Child Health, 29(3), pp. 196-200.
Cystic fibrosis (CF) patients require pancreatic enzyme replacement therapy to correct pancreatic insufficiency. These enzymes are derived from porcine pancreas and are known to be antigenic. To determine the possible clinical consequences, a specific ELISA was developed to detect IgG antibody directed against porcine trypsin (PTAb) in the sera of CF patients. The assay was used to evaluate the occurrence of PTAb in a cross sectional study of 103 CF patients in relation to the introduction of porcine enzyme therapy, clinical status and genotype. Antibodies against porcine trypsin were detected in the sera of 63% of patients unrelated to the age of commencement or the duration of enzyme therapy. No differences were observed in the clinical status of CF patients who had developed PTAb (n = 65) and those who had no detectable PTAb (n = 38) as determined from: the current prescribed dose of porcine pancreatic enzyme capsules; Z scores for height and weight; and respiratory function tests. It is suggested that the PTAb commonly found in the sera of CF patients are of doubtful clinical significance but the prospect of PTAb contributing to immune complex disease should be examined further.
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|Item Type:||Journal Article|
|Additional Information:||Cited By :2
Export Date: 1 September 2015
Correspondence Address: Cleghorn, G.; Department of Child Health, University of Queensland, Royal Children's Hospital, Herston, QLD 4029, Australia
|Keywords:||cystic fibrosis, immunoglobulin G, pancreatic enzyme supplements, porcine trypsin, immunoglobulin g antibody, pancreas enzyme, trypsin, antibody detection, antigenicity, article, enzyme linked immunosorbent assay, human, major clinical study, pancreas exocrine insufficiency, priority journal, Adolescent, Animal, Child, Child, Preschool, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Pancreatic Extracts, Pancreatic Insufficiency, Swine|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Exercise & Nutrition Sciences
|Deposited On:||13 Nov 2015 03:02|
|Last Modified:||13 Nov 2015 03:02|
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