Medication adherence of individuals with a first episode of psychosis

Coldham, E.L., Addington, J., & Addington, D. (2002) Medication adherence of individuals with a first episode of psychosis. Acta Psychiatrica Scandinavica, 106(4), pp. 286-290.

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To determine rates of adherence to antipsychotic medication in first episode patients and the correlates of adherence in this group.


Subjects were the first 200 admissions to an Early Psychosis Program. Adherence was determined on a three-point scale. Symptoms, medication side-effects, quality of life, substance use and family involvement were examined longitudinally.


In their first year in the program 39% were non-adherent, 20% inadequately adherent, and 41% adherent. Non-adherent patients demonstrated more positive symptoms, more relapses, more alcohol and cannabis use, reduced insight, and poorer quality of life. They were younger, had an earlier age of onset and less likely to have a family member involved in treatment.


Results for this group are similar to those reported in the literature. Correlates are often the consequence of non-adherence. Non-compliance has to be anticipated and relationships maintained with patients and families to intervene as soon as possible to minimize the consequence of non-compliance.

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ID Code: 90168
Item Type: Journal Article
Refereed: Yes
Additional Information: Eliana Coldham (E.L. Coldham) is the maiden name of Eliana Close
Keywords: Patient non-adherence, Psychotic disorders, Schizophrenia, Drug utilization
DOI: 10.1034/j.1600-0447.2002.02437.x
ISSN: 1600-0447
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)
Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Health Clinical and Counselling Psychology (170106)
Divisions: Current > QUT Faculties and Divisions > Faculty of Law
Current > Research Centres > Australian Centre for Health Law Research
Current > Schools > School of Law
Deposited On: 12 Nov 2015 00:57
Last Modified: 12 Nov 2015 00:57

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