Effect of age and refractive error on the melanopsin mediated Post-Illumination Pupil Response (PIPR)

Adhikari, Prakash, Pearson, Candice, Anderson, Alexandra, Zele, Andrew J., & Feigl, Beatrix (2015) Effect of age and refractive error on the melanopsin mediated Post-Illumination Pupil Response (PIPR). Scientific Reports, 5, Articale Number 17610.

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Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease, however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

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ID Code: 90219
Item Type: Journal Article
Refereed: Yes
Additional URLs:
ISSN: 2045-2322
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2015 The Author(s)
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Deposited On: 15 Nov 2015 23:45
Last Modified: 05 Mar 2016 04:07

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