Standardised antibacterial Manuka honey in the management of persistent post-operative corneal oedema: A case series

Albietz, Julie M. & Lenton, Lee M. (2015) Standardised antibacterial Manuka honey in the management of persistent post-operative corneal oedema: A case series. Clinical and Experimental Optometry, 98(5), pp. 464-472.

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Abstract

Background

Corneal oedema is a common post-operative problem that delays or prevents visual recovery from ocular surgery. Honey is a supersaturated solution of sugars with an acidic pH, high osmolarity and low water content. These characteristics inhibit the growth of micro-organisms, reduce oedema and promote epithelialisation. This clinical case series describes the use of a regulatory approved Leptospermum species honey ophthalmic product, in the management of post-operative corneal oedema and bullous keratopathy.

Methods

A retrospective review of 18 consecutive cases (30 eyes) with corneal oedema persisting beyond one month after single or multiple ocular surgical procedures (phacoemulsification cataract surgery and additional procedures) treated with Optimel Antibacterial Manuka Eye Drops twice to three times daily as an adjunctive therapy to conventional topical management with corticosteroid, aqueous suppressants, hypertonic sodium chloride five per cent, eyelid hygiene and artificial tears. Visual acuity and central corneal thickness were measured before and at the conclusion of Optimel treatment.

Results

A temporary reduction in corneal epithelial oedema lasting up to several hours was observed after the initial Optimel instillation and was associated with a reduction in central corneal thickness, resolution of epithelial microcysts, collapse of epithelial bullae, improved corneal clarity, improved visualisation of the intraocular structures and improved visual acuity. Additionally, with chronic use, reduction in punctate epitheliopathy, reduction in central corneal thickness and improvement in visual acuity were achieved. Temporary stinging after Optimel instillation was experienced. No adverse infectious or inflammatory events occurred during treatment with Optimel.

Conclusions

Optimel was a safe and effective adjunctive therapeutic strategy in the management of persistent post-operative corneal oedema and warrants further investigation in clinical trials.

Impact and interest:

1 citations in Scopus
2 citations in Web of Science®
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ID Code: 90236
Item Type: Journal Article
Refereed: Yes
Keywords: Manuka honey, bullous keratopathy, cataract surgery, cornea, corneal oedema
DOI: 10.1111/cxo.12295
ISSN: 1444-0938
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > COMPLEMENTARY AND ALTERNATIVE MEDICINE (110400) > Complementary and Alternative Medicine not elsewhere classified (110499)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Optometry & Vision Science
Copyright Owner: Copyright 2015 The Authors
Copyright Statement: This is the peer reviewed version of the following article: Albietz, J. M., and Lenton, L. M. (2015) Standardised antibacterial Manuka honey in the management of persistent post-operative corneal oedema: a case series. Clin Exp Optom, 98: 464–472., which has been published in final form at doi: 10.1111/cxo.12295. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Deposited On: 16 Nov 2015 00:38
Last Modified: 03 Sep 2016 03:32

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